Understanding Neurodegeneration and Alzheimer's Disease with Professor Susan Greenfield
Understanding Neurodegeneration and Alzheimer's Disease with Professor Susan Greenfield
Coming Soon to Enjoy Life Healthier Podcast! In this episode, we had the privilege of speaking with Professor Susan Greenfield, a world-renowned neuroscientist from Oxford University and the founder of NeuroBio, a pharmaceutical company dedicated to developing treatments for Alzheimer’s disease and neurodegeneration.
If you or a loved one has been affected by dementia or Alzheimer’s, this episode is a must-listen! Let’s dive into key takeaways from our conversation.
What is Neurodegeneration?
Neurodegeneration refers to the gradual and progressive loss of neurons (brain cells), which leads to debilitating conditions like:
Alzheimer’s disease – Characterized by memory loss, confusion, and disorientation.
Parkinson’s disease – Marked by tremors, muscle rigidity, and slowed movement.
ALS (Motor Neuron Disease) – Affects voluntary muscle control and strength.
These conditions present different symptoms, but Professor Greenfield explains that they may share common underlying mechanisms, making research into early intervention and treatment essential.
Dementia vs. Alzheimer’s: What’s the Difference?
One of the most common misconceptions is the difference between dementia and Alzheimer’s.
Dementia is an umbrella term for cognitive decline severe enough to interfere with daily life.
Alzheimer’s disease is the most common type of dementia, making up 70% of all cases.
Professor Greenfield emphasizes that dementia is more than just forgetfulness—it leads to a progressive loss of identity, making it difficult for individuals to recognize loved ones and function independently.
Early Signs of Dementia & Alzheimer’s
Recognizing early warning signs can help individuals seek medical advice sooner. Common symptoms include:
Short-term memory loss – Forgetting recent conversations while recalling distant memories.
Repetitive speech – Saying the same thing multiple times without realizing it.
Declining vocabulary – Struggling to find words or using unusual phrases.
Unusual behaviors – Performing tasks irrationally, such as putting objects in odd places.
Loss of reasoning – Making illogical decisions or statements.
If you notice these signs in a loved one, consult a healthcare professional for further evaluation.
Risk Factors for Alzheimer’s Disease
While genetics play a role, Alzheimer’s is not exclusively hereditary. Key risk factors include:
Age – The most significant risk factor, as the brain naturally ages.
Head injuries – Trauma from accidents or contact sports.
Poor cardiovascular health – High blood pressure and cholesterol can affect brain function.
Lack of social interaction – Cognitive decline is accelerated by isolation.
Sedentary lifestyle – Regular exercise significantly improves brain health.
Preventative Measures: What Can You Do?
While there is no guaranteed way to prevent Alzheimer’s, Professor Greenfield suggests several lifestyle changes that may reduce risk:
Exercise regularly – People who stay active score higher on cognitive function tests.
Stay socially engaged – Conversations and social interactions build cognitive reserve.
Eat a brain-healthy diet – Leafy greens, fish, and blueberries provide essential nutrients.
Avoid smoking & excessive alcohol – These habits increase oxidative stress in the brain.
Keep learning – Engaging in puzzles, reading, or learning a new skill stimulates brain function.
NeuroBio’s Groundbreaking Research: A New Hope for Alzheimer’s
Professor Greenfield’s company, NeuroBio, is developing two revolutionary innovations:
A Pre-Symptomatic Test for Alzheimer’s
A nasal swab or saliva test that can detect Alzheimer’s years before symptoms appear.
A Potential Breakthrough Drug (NBP-14)
A first-of-its-kind medication designed to halt neurodegeneration rather than just slow it down.
Unlike existing treatments that target amyloid plaques, NeuroBio’s research focuses on T14, a protein linked to brain cell death. This could be the first real treatment that stops Alzheimer’s before it begins.
The Future of Alzheimer’s Treatment
So when could these innovations become reality?
Nasal test: Expected to be available within 1–2 years.
Alzheimer’s drug (NBP-14): Currently in animal trials, with human trials expected within 2–3 years.
This research represents a paradigm shift in Alzheimer’s treatment, giving hope to millions worldwide.
Final Thoughts
Professor Greenfield shared her vision for the future of Alzheimer’s treatment:
“My hope is that, one day, people will look back on Alzheimer’s the way we now think of smallpox or polio—conditions that once devastated families but are now completely preventable. We aim to create a world where a simple test at your annual checkup can detect early neurodegeneration, and a safe, effective treatment can halt it before symptoms even begin. If we can make that happen, we will have changed countless lives for the better.”
Alzheimer’s is one of the most devastating diseases families face today, but with early detection and innovative treatments, the future looks promising. Professor Greenfield’s work at NeuroBio could change the way we diagnose, prevent, and treat neurodegenerative diseases forever.
Want to learn more? Visit NeuroBio’s website to explore their groundbreaking research.
Listen to the full episode on Enjoy Life Healthier Podcast wherever you get your podcasts!
Have thoughts on these advancements? Have you or a loved one been affected by Alzheimer’s? Share your experiences in the comments below!
This Episode will be Available Sunday, April 6, 2025 on our YouTube Channel.
Enjoy Life Healthier,